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Roxidolin 100mg 10 Pills, Doxicicline

Roxidolin 100mg 10 Pills, Doxicicline
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Roxidolin 100mg 10 Pills, Doxicicline

THERAPEUTIC INDICATIONS: Doxycycline is indicated for infections caused by the following microorganisms: Rickettsiae: spotted fever Rocky Mountains, typhus and typhus fever, Q fever Rickettsialpox and tick fever.

Mycoplasma pneumoniae (Eaton agent, PPLO). Chlamydia psittaci, formerly agent of psittacosis and ornithosis. Chlamydia trachomatis, formerly agent of lymphogranuloma venereum.

Doxycycline is indicated for the treatment of uncomplicated infections of the urethra, endocervix or rectum of adults due to Chlamydia trachomatis.

Calymmatobacterium (Donovania) granulomatosis (formerly agents of granuloma inguinale). Borrelia recurrentis and B. Dutton, the spirochete responsible for relapsing fever transmitted by lice and ticks. Ureaplasma urealyticum (mycoplasma T), as agent of nongonococcal urethritis in men and associated with infertility. Plasmodium falciparum (P. falciparum malaria resistant to chloroquine).

Doxycycline may be useful in case of acute intestinal amebiasis, along with the administration of amebicides it can also be useful adjunct therapy in the treatment of severe acne.

Doxycycline is indicated for the treatment of trachoma, although the causal agent, according to the immunofluorescence tests, has not always been removed.

Is indicated for the treatment of stage I of Lyme disease. Additionally, you can treat inclusion conjunctivitis, either with single oral administration of doxycycline combining it with topical agents.

Doxycycline is indicated for prophylaxis in the following cases:

Typhus (Rickettsia tsutsugamushi).

Tourist diarrhea (enterotoxigenic Escherichia coli).

Malaria (in areas where Plasmodium falciparum is resistant to chloroquine).

Pharmacokinetics in Humans: Doxycycline is a bacteriostatic for gram-positive and gram-negative and is believed to be its antibacterial effect by inhibiting protein synthesis.

Tetracyclines are readily absorbed and fixed to plasma proteins to varying degrees. They are concentrated by the liver into bile and excreted in urine and feces at high concentrations and biologically active form. Doxycycline is almost completely absorbed after oral administration.

The studies reported to date indicate that the absorption of doxycycline is not modified significantly by the ingestion of food, including milk, unlike what is observed with some tetracyclines.

After administration in normal adult volunteers a dose of 200 mg, serum levels reach a maximum of 2.6 mcg / ml after 24 hours.The studies have shown no significant difference in half-life of doxycycline (range 18 to 22 hours) in patients with severely impaired renal function. Haemodialysis does not change the plasma half-life of doxycycline.

CONTRAINDICATIONS: Patients who have shown hypersensitivity to any of the tetracyclines.

PRECAUTIONS: As seen with other tetracyclines, doxycycline forms a stable calcium complex in any osteogenic tissue. It has been a decrease in fibula growth rate in premature infants who received 25 mg / kg of tetracycline orally every 6 hours. This reaction was shown to be reversible when the drug discontinued.

The use of antibiotics may occasionally lead to the development of non-susceptible organisms. It is essential to the constant observation of the patient. If infection by resistant organisms, the antibiotic should be discontinued and appropriate therapy instituted.

When during the treatment of venereal disease is suspected the coexistence of syphilis, should be diagnostic procedures, including dark-field examination. In all these cases, monthly serological tests should be performed at least four months.

In the long-term treatment must undergo periodic laboratory evaluations of organ systems, including studies hematopoietic, renal and liver.

Photosensitivity has been observed in some individuals taking tetracyclines, in the form of an exaggerated sunburn. Patients who for any reason be exposed to direct sunlight or ultraviolet radiation should be informed of this reaction by the use of tetracyclines, and the first sign of redness administration should be discontinued.

Antianabolic action of tetracyclines may lead to increased blood urea nitrogen. Studies conducted to date indicate that this does not happen when using doxycycline in patients with renal insufficiency.

Use in Pregnancy and Lactation

Use in pregnancy: Not rated yet doxycycline in pregnant women, so not recommended for use during pregnancy.

Lactation: The tetracyclines pass into breast milk of nursing women, why they should be avoided in his administration.

Use in children: The use of drugs in the tetracycline class during tooth development (last half of pregnancy, infancy and childhood to 8 years old) can lead to permanent discoloration of the teeth (yellow-gray-brown .) This undesirable reaction is more common with prolonged use, although it has been observed following repeated short treatments. Have also been reported cases of enamel hypoplasia. Therefore not be used doxycycline in the age groups listed above, unless no other antibiotics are available, which if present is unlikely to be effective or, rather, they are contraindicated.

ADVERSE REACTIONS: Because the absorption of doxycycline is almost complete, gastrointestinal adverse effects are rare. Have observed the following side effects in patients who have received tetracyclines.

Gastrointestinal: Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, and inflammatory processes of the anogenital region (with growth of Candida albicans).

Rarely reported liver dysfunction. These reactions have been observed with the administration of tetracyclines both orally and parenterally.

Have been reported rarely esophagitis and esophageal ulcers in patients receiving oral tetracyclines. Most of these patients took the medication immediately before bedtime.

Skin: maculopapular and erythematous rash. Although rare, there have been reports of exfoliative dermatitis. Photosensitivity is discussed in section precautions.

Hypersensitivity reactions: Urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis and exacerbation of lupus erythematosus.

It has been reported bulging fontanelles in infants and benign intracranial hypertension in adults who have received therapeutic doses. These effects disappear rapidly on discontinuation of administration.

When given a tetracycline for prolonged periods, has reported the appearance of microscopic spots of dark brown in the thyroid gland, but no reported functional disorders of the thyroid.

DRUG INTERACTIONS AND OTHER GENDER: Because tetracyclines have been shown to decrease plasma prothrombin activity, patients who are receiving anticoagulant therapy may require adjustment, reducing the dose of anticoagulant.

Since bacteriostatic drugs may interfere with the bactericidal effect of penicillin, doxycycline is not recommended and penicillin administered concomitantly.

The absorption of the tetracycline is altered by the aluminum-containing antacids, calcium or magnesium, as well as preparations containing iron and bismuth salts.

Barbiturates, alcohol, carbamazepine and phenytoin decrease the half-life of doxycycline.


Renal toxicity: It is reported increased blood urea nitrogen when used tetracycline, apparently dose related.

Blood: There have been reports of hemolytic anemia, thrombocytopenia, and eosinophilia etropenia.

PRECAUTIONS IN RELATION TO EFFECTS OF CARCINOGENESIS, MUTAGENESIS, Impairment of Fertility: Results from animal studies indicate that tetracyclines cross the placenta, are found in fetal tissues and can result in toxic effects in the same ( usually in conjunction with delayed skeletal development). There has also been evidence of embryotoxicity in animals treated during early pregnancy.

DOSAGE AND ADMINISTRATION: Treatment should be continued for at least 24 or 48 hours after symptoms and fever have subsided. In case of streptococcal infections, therapy should be continued for 10 days, to prevent the development of rheumatic fever or glomerulonephritis.

The usual dose of doxycycline in adults is 200 mg on the first day of treatment (administered in a single dose or 2 doses of 100 mg every 12 hours), followed by a maintenance dose of 100 mg / day.

In the treatment of more severe infections (particularly chronic urinary tract infections) may be administered 200 mg daily for treatment.

Children over 8 years: The recommended dosage schedule for children weighing 50 kg or less is 4 mg / kg the first day of treatment (1 or 2 doses). In more severe infections can be used up to 4 mg / kg daily. In children over 50 kg the recommended dose should be used for adults (see use in children).

Acne vulgaris: 50-100 mg daily for up to 12 weeks.

Uncomplicated gonococcal infections (except anorectal infections in men): 100 mg orally, 2 times daily for 7 days. As alternative scheme of single dose 300 mg can be given immediately, and an hour later, another 300 mg. The medication must be given with food, including milk or carbonated beverages.

Infection urethral, ​​endocervical or rectal adult uncomplicated, caused by Chlamydia trachomatis: 100 mg orally, 2 times a day for a minimum of 10 days. In case of infections by Ureaplasma urealyticum (mycoplasma T) in the male genital tract, the patient and her partner should be treated with 100 mg 2 times daily for 4 weeks.

Nongonococcal urethritis caused by Ureaplasma urealyticum: 100 mg orally, 2 times daily for 7 days.

Primary and secondary syphilis: 300 mg daily in divided doses for at least 10 days.

Pelvic inflammatory disease in outpatients: are recommended 2 g of cefoxitin intramuscularly or 3 g of amoxicillin or ampicillin 3.5 g orally or 4.8 million units of penicillin G procaine IM applied at two different sites, or ceftriaxone 250 mg IM Each of these diagrams, except ceftriaxone, must be accompanied by oral administration of 1 g of prebenecid, followed by 100 mg doxycycline orally, 2 times a day for 10-14 days.

Plasmodium falciparum resistance to chloroquine 200 mg daily for at least 7 days. There must be a fast-acting schizontocide, such as quinine, together with doxycycline. The recommended dose of quinine varies. Prophylaxis can begin 1-2 days before travel to malarious areas. Treatment should continue during the trip and 4 weeks after leaving such areas.

Prophylaxis of malaria:

Adults: 100 mg daily.

Children over 8 years: 2 mg / kg daily with a maximum equal to the adult dose.

The louse-borne relapsing fever and tick, and epidemic typhus were treated successfully with a single oral dose of 100 or 200 mg depending on its severity.

Treatment and selective prophylaxis of cholera in adults: 300 mg as a single dose.

Prevention of typhus: 200 mg as single dose.

Prevention of traveler's diarrhea (adults): 200 mg during the first travel day (administered as a single dose or 100 mg every 12 hours), followed by 100 mg daily while in the area of ​​risk. There are no data on the prophylactic effect when using the antibiotic for more than 21 days.

Prevention of leptospirosis: 100 mg orally two times daily for 7 days.

Studies done to date have indicated that administration of doxycycline in usual recommended doses does not lead to excessive accumulation of the antibiotic in patients with renal insufficiency.

Administration: Patients are advised to ingest sufficient quantities of liquid while under treatment with tetracycline drug orally to reduce the possibility of irritation or ulceration of the esophagus. If gastric irritation occurs, it is recommended that doxycycline be ingested with food or milk. Studies indicate that absorption of doxycycline is not affected significantly when ingested simultaneously with food.

REPRESENTATIONS AND MANAGEMENT Overdosage: The usual dose and frequency of administration of doxycycline differ from other tetracyclines. Excess in the recommended amounts may result in an increased frequency of side effects. No data from the prophylactic effect when using the antibiotic for more than 21 days.

In case of overdosage, discontinue medication, treat symptoms and institute supportive measures. Dialysis does not alter the serum half-life and, therefore, would not be beneficial in the treatment of cases of overdosage.
Drug Name: Roxidolin
Brand comparison: Vivradoxil
Active substance: Doxycycline
Presentation: Capsules
Concentration: 100 mg
Response time: No
Lab: Raam, S. A. de CV
Bottle with 10 Pills
Manufactured in: Mexico

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